Protein CRP map

Identifiers
HUGO:CRP

Maps_Modules
MODULE:INPUT_ACTIVATORS MODULE:TUMOR_RECOGNTITON MODULE:FC_RECEPTORS

References
 NEUTROPHIL  map
CASCADE:Fc_gamma_RI
CASCADE:Fc_gamma_RII
PMID:3489521, PMID:11801683, PMID:15531769
Macrophage tumoricidal activity induced by human C-reactive protein.
Probably through Fc gamma RIIa and FcγRI receptors and PI3K, PLCG pathways.
This pathway is involeved also in neutrophil activity regulation.

Modifications:
In compartment: TUMOR_CELL_AS_INDUCTOR_Membrane
  1. CRP@TUMOR_CELL_AS_INDUCTOR_Membrane map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
      As Catalyser:
      1. Immunoglobulins*@TUMOR_CELL_AS_INDUCTOR map + Fc_gamma_RII_activating*@INNATE_IMMUNE_CELL_Membrane map → map Fc_gamma_RII_activating*|​pho:​Immunoglobulins*@INNATE_IMMUNE_CELL_Membrane map
      2. Immunoglobulins*@TUMOR_CELL_AS_INDUCTOR map + Fc_gamma_RI*@INNATE_IMMUNE_CELL_Membrane map + FCER1G@INNATE_IMMUNE_CELL_Membrane map → map FCER1G|​pho:​Fc_gamma_RI*:​Immunoglobulins*@INNATE_IMMUNE_CELL_Membrane map