Protein p53* map

Identifiers
HUGO:TP53

References
 NATURAL_KILLER  map
PMID:22754780, PMID:21764762
Wild-type p53, but not mutant p53 interacts with UDLPs promoters and induces UDLP2 and UDLP1 expression in tumor cells and increases tumor immunogenicity.
UDLPs activate NKG2D* signaling in NK cells.Induction of wtp53 expression in tumor cells leads to their enhanced recognition by primary NK cells in a NKG2D-dependent manner.
PMID:22102694
Activation of p53 by Nutlin3a resulted in upregulation of Mir34a/c expression and decreased ULBP2 expression in several tumor models (but not in the all models).

Modifications:
In compartment: TUMOR_CELL_AS_INDUCTOR
  1. p53*@TUMOR_CELL_AS_INDUCTOR map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
      As Catalyser:
      1. gULBP2@TUMOR_CELL_AS_INDUCTOR map → map rULBP2@TUMOR_CELL_AS_INDUCTOR map
      2. gUDLP1@TUMOR_CELL_AS_INDUCTOR map → map rUDLP1@TUMOR_CELL_AS_INDUCTOR map
      3. gMIR34A@TUMOR_CELL_AS_INDUCTOR map → map arMIR34A@TUMOR_CELL_AS_INDUCTOR map
      4. gMIR34C@TUMOR_CELL_AS_INDUCTOR map → map arMIR34C@TUMOR_CELL_AS_INDUCTOR map