Protein LGMN map

Identifiers
HUGO:LGMN

Maps_Modules
MODULE:IMMUNE_STIMULATION MODULE:ANTIGEN_PRESENTATION MODULE:EFFECTOR_ACTIVATION

References
 DENDRITIC_CELL  map
PMID:16181339, PMID:12705852
Processing of CD74 includes its initial cleavage by Legumain, followed by late stage cleavage by Cathepsin S and Cathepsin L
PMID:12776207, PMID:10795737, PMID:17204652
Cathepsins B,D,L, S and AEP (LGMN) are the lysosomal proteases implicated in antigen presentation in DC.

Modifications:
In compartment: PHAGOSOME/ENDOSOME/LYSOSOME_Membrane
  1. LGMN@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
      As Catalyser:
      1. Tumor_antigen@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map → map Tumor_antigen_fragment@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map
      2. CD74:​MHC_class_II*@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map → map CLIP*:​MHC_class_II*@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map