Protein PDIA3 map

Identifiers
HUGO:PDIA3

Maps_Modules
MODULE:IMMUNE_STIMULATION MODULE:ANTIGEN_PRESENTATION MODULE:EFFECTOR_ACTIVATION

References
 DENDRITIC_CELL  map
PMID:16181333, PMID:22076556
PDIA3(ERp57) is a disulfide isomerase it is a non-covalently associated component of the peptide-loading complex.
PMID:17204652
DCs, which are biased for MHCI cross-presentation, were enriched in Tap1, Tap2, calreticulin, calnexin, Sec61, ERp57, ERAAP, as well as cystatin B and C, all of which are involved in MHCI presentation or inhibition of enzymes that process peptides
PMID:14508489
Together with TAP, tapasin, calreticulin, ERp57 and the heavy chain of MHC class I were all detected in purified early phagosomes by western blotting

Modifications:
Participates in complexes:
In compartment: Endoplasmic Reticulum_Membrane
  1. CALR:​PDIA3@Endoplasmic Reticulum_Membrane map
In compartment: PHAGOSOME/ENDOSOME/LYSOSOME_Membrane
  1. CALR:​PDIA3@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map
Participates in reactions:
As Reactant or Product:
    As Catalyser:
    1. B2M:​MHC_class_I*@Endoplasmic Reticulum_Membrane map + Tumor_antigen_fragment@Endoplasmic Reticulum_Membrane map → map B2M:​MHC_class_I*:​Tumor_antigen_fragment@Endoplasmic Reticulum_Membrane map
    2. B2M:​MHC_class_I*@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map + Tumor_antigen_fragment@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map → map B2M:​MHC_class_I*:​Tumor_antigen_fragment@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map