Reaction state_transition d_re437 map

No DNA replicarion@default map → DNA replicarion@default map

Reaction regulators:
Boolean_logic_gate_and
  1. CDC45:​CDC6:​CDT1:​MCM2:​MCM3:​MCM4:​MCM5:​MCM6:​MCM7:​ORC1*:​ORC2*:​ORC3*:​ORC4*:​ORC5*:​ORC6*:​POLA*:​PRIM*:​RPA1:​RPA2:​RPA3@default map and GINS1:​GINS2:​GINS3:​GINS4@default map and TIM1*:​TIPIN@default map
Catalysis
  1. CDC45:​CDC6:​CDT1:​MCM2:​MCM3:​MCM4:​MCM5:​MCM6:​MCM7:​ORC1*:​ORC2*:​ORC3*:​ORC4*:​ORC5*:​ORC6*:​POLA*:​PRIM*:​RPA1:​RPA2:​RPA3@default map
  2. GINS1:​GINS2:​GINS3:​GINS4@default map
  3. TIM1*:​TIPIN@default map
Inhibition
  1. BRCA1:​SMC1*|​S957_pho@default map
  2. BRCA1:​SMC3|​S1083_pho@default map
  3. ATRIP:​ATR|​pho:​CHEK1|​pho:​CLSPN|​pho:​PCNA|​K164_ubi:​TIM1*@default map
Trigger
  1. gRepaired_DNA*@Nucleus map


References
For role of TIM1*/TIPIN in S-phase checkpoint, stalled replication forks stabilisation and DNA repair during S-phase:
PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221
Stalled replication forks induce PCNA mono-ubiquitylation and formation of the complex that activated TLS and arrests S-phase:
PMID:19793801, PMID:17582221, PMID:19158510, PMID:18451105

Confidence
REF=4 FUNC=3