Reaction heterodimer_association re17 map

MDA-5@Cytoplasm map + MAVs@Mitochondria map → MAVs:​MDA-5@Mitochondria map

No reaction regulators




IPS-1 /MAV associated with the CARD region of RIG-I or MDA5 through its own CARD.
PMID:16474426; Seth, R. B., Sun, L. & Chen, Z. J. Antiviral innate immunity pathways. Cell Res 16, 141-7 (2006).
PMID:16127453; Kawai, T. et al. IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nat Immunol 6, 981-8 (2005).
PMID:16125763; Seth, R. B., Sun, L., Ea, C. K. & Chen, Z. J. Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3. Cell 122, 669-82 (2005).
PMID:16785313. .Kumar H, Kawai T, Kato H, Sato S, Takahashi K, Coban C, Yamamoto M, Uematsu S, Ishii KJ, Takeuchi O, Akira S.
Essential role of IPS-1 in innate immune responses against RNA viruses.J Exp Med. 2006 Jul 10;203(7):1795-803. Epub 2006 Jun 19.