Reaction heterodimer_association re136 map

IKKE@Cytoplasm map + TBK1@Cytoplasm map + TANK@Cytoplasm map → (IKKE:​TANK:​TBK1)|​active@Cytoplasm map

Reaction regulators:
Catalysis
  1. RIG-I|​ubi:​TRAF3@Mitochondria map





PMID:17327220; Beichu Guo and Genhong ChengModulation of the Interferon Antiviral Response by the TBK1/IKKi Adaptor Protein TANK. J. Biol. Chem., Vol. 282, Issue 16, 11817-11826, April 20, 2007
PMID:12133833. Chariot A, Leonardi A, Muller J, Bonif M, Brown K, Siebenlist U.Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases. J Biol Chem. 2002 Oct 4;277(40):37029-36. Epub 2002 Jul 19.
PMID:16281057. Huang J, Liu T, Xu LG, Chen D, Zhai Z, Shu HB.SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways.EMBO J. 2005 Dec 7;24(23):4018-28. Epub 2005 Nov 10.
PMID:14560022.Fujita F, Taniguchi Y, Kato T, Narita Y, Furuya A, Ogawa T, Sakurai H, Joh T, Itoh M, Delhase M, Karin M, Nakanishi M. Identification of NAP1, a regulatory subunit of IkappaB kinase-related kinases that potentiates NF-kappaB signaling. Mol Cell Biol. 2003 Nov;23(21):7780-93.
PMID:16474426; Seth, R. B., Sun, L. & Chen, Z. J. Antiviral innate immunity pathways. Cell Res 16, 141-7 (2006).
PMID:16452304; Sasai, M., Matsumoto, M. & Seya, T. The Kinase Complex Responsible for IRF-3-Mediated IFN-{beta} Production in Myeloid Dendritic Cells (mDC). J Biochem (Tokyo) 139, 171-5 (2006).
PMID:16309964; Johnson, C. L. & Gale, M., Jr. CARD games between virus and host get a new player. Trends Immunol 27, 1-4 (2006).
PMID:12692549; Fitzgerald, K. A. et al. IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway. Nat Immunol 4, 491-6 (2003).
PMID:16914100 Paz S,Sun Q,Nakhaei P,Romieu-Mourez R,Goubau D,Julkunen I,Lin R,Hiscott J. Induction of IRF-3 and IRF-7 phosphorylation following activation of the RIG-I pathway.Cell Mol Biol (Noisy-le-grand). 2006 May 15;52(1):17-28.
PMID:17142768.Sasai M,Shingai M,Funami K,Yoneyama M, Fujita T,Matsumoto M,Seya T.NAK-associated protein 1 participates in both the TLR3 and the cytoplasmic pathways in type I IFN induction.J Immunol. 2006 Dec 15;177(12):8676-83.
PMID:16125763. Seth RB, Sun L, Ea CK, Chen ZJ.Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3. Cell. 2005 Sep 9;122(5):669-82.