Reaction heterodimer_association re162 map

RIG-I@Cytoplasm map + MAVs@Mitochondria map + TRAF3@Cytoplasm map → RIG-I|​ubi:​TRAF3@Mitochondria map

Reaction regulators:
Inhibition
  1. NLRX1@Mitochondria map
  2. Triad3A@Cytoplasm map





PMID:18200010; Chris B. Moore, Daniel T. Bergstralh, Joseph A. Duncan, Yu Lei, Thomas E. Morrison, Albert G. Zimmermann, Mary A. Accavitti-Loper, Victoria J. Madden, Lijun Sun, Zhengmao Ye, John D. Lich, Mark T. Heise, Zhijian Chen & Jenny P-Y. Ting. NLRX1 is a regulator of mitochondrial antiviral immunity. Nature 451, 573-577 (31 January 2008)
PMID:16474426; Seth, R. B., Sun, L. & Chen, Z. J. Antiviral innate immunity pathways. Cell Res 16, 141-7 (2006).
PMID:16127453; Kawai, T. et al. IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nat Immunol 6, 981-8 (2005).
PMID:16125763; Seth, R. B., Sun, L., Ea, C. K. & Chen, Z. J. Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3. Cell 122, 669-82 (2005).
PMID:16153868; Xu, L.-G.; Wang, Y.-Y.; Han, K.-J.; Li, L.-Y.; Zhai, Z.; Shu, H.-B.VISA is an adapter protein required for virus-triggered IFN-beta signaling. Molec. Cell 19: 727-740, 2005.
PMID:16785313; Kumar H, Kawai T, Kato H, Sato S, Takahashi K, Coban C, Yamamoto M, Uematsu S, Ishii KJ, Takeuchi O, Akira S. Essential role of IPS-1 in innate immune responses against RNA viruses.J Exp Med. 2006 Jul 10;203(7):1795-803. Epub 2006 Jun 19.
PMID:15208624; Yoneyama, M. et al. The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nature Immunol. 5, 730–737 (2004)
PMID:19893624; Nakhaei P, Mesplede T, Solis M, Sun Q, Zhao T, Yang L, Chuang TH, Ware CF, Lin R, Hiscott J.The E3 ubiquitin ligase Triad3A negatively regulates the RIG-I/MAVS signaling pathway by targeting TRAF3 for degradation.PLoS Pathog. 2009 Nov;5(11):e1000650. Epub 2009 Nov 6.