Reaction state_transition re2
IKB:NFKB(p65-p50dimer)|hm2@Cytoplasm
→ IKB|pho:NFKB(p65-p50dimer)|hm2@Cytoplasm
Reaction regulators:
- Catalysis
- IKK1:IKK2|pho:NEMO|ubi@Cytoplasm
- IKK2|pho:IKKE:NEMO|ubi@Cytoplasm
- CASP8_CLEAVED@Cytoplasm
- CASP10_CLEAVED@Cytoplasm
PMID:9804849.Li J, Peet GW, Pullen SS, Schembri-King J, Warren TC, Marcu KB, Kehry MR, Barton R, Jakes S. Recombinant IkappaB kinases alpha and beta are direct kinases of Ikappa Balpha.J Biol Chem. 1998 Nov 13;273(46):30736-41.
PMID:9244310. Regnier, C. H. et al. Identification and characterization of an IkappaB kinase. Cell 90, 373-83 (1997).
PMID:10837071. Karin, M. & Ben-Neriah, Y. Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. Annu Rev Immunol 18, 621-63 (2000).
PMID:16585540.Takahashi K, Kawai T, Kumar H, Sato S, Yonehara S, Akira S. Roles of caspase-8 and caspase-10 in innate immune responses to double-stranded RNA. J Immunol. 2006 Apr 15;176(8):4520-4.