Reaction state_transition re6 map

PRK@Cytoplasm map → PRK|​pho|​hm2@Cytoplasm map

Reaction regulators:
Catalysis
  1. dsRNA@Cytoplasm map





PMID:11432733.Vattem KM,Staschke KA,Wek RC. Mechanism of activation of the double-stranded-RNA-dependent protein kinase, PKR: role of dimerization and cellular localization in the stimulation of PKR phosphorylation of eukaryotic initiation factor-2 (eIF2).Eur J Biochem. 2001 Jul;268(13):3674-84.Click here to read Links
PMID:11337501.Zhang F, Romano PR, Nagamura-Inoue T, Tian B, Dever TE, Mathews MB, Ozato K, Hinnebusch AG. Binding of double-stranded RNA to protein kinase PKR is required for dimerization and promotes critical autophosphorylation events in the activation loop. J Biol Chem. 2001 Jul 6;276(27):24946-58. Epub 2001 May 3.
PMID:15229216. Silva AM, Whitmore M, Xu Z, Jiang Z, Li X, Williams BR. Protein kinase R (PKR) interacts with and activates mitogen-activated protein kinase kinase 6 (MKK6) in response to double-stranded RNA stimulation.J Biol Chem. 2004 Sep 3;279(36):37670-6.