Reaction state_transition re7 map

MKK4@Cytoplasm map → MKK4@Cytoplasm map

Reaction regulators:
Catalysis
  1. MEKK1@Cytoplasm map
  2. TAK1 |​pho|​active@Cytoplasm map





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PMID:9808624. Xia Y, Wu Z, Su B, Murray B, Karin M.JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension.Genes Dev. 1998 Nov 1;12(21):3369-81.
PMID:10882101. Takaesu, G. et al. TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway. Mol. Cell 5, 649-658 (2000)
PMID:11057907.Deng, L. et al. Activation of the IkappaB kinase complex requires a dimeric ubiquitin conjugating enzyme complex and a unique polyubiquitin chain. Cell 103, 351-361 (2000).
PMID:11460167. Chen Wang1,2, Li Deng1,2, Mei Hong1, Giridhar R. Akkaraju1, Jun-ichiro Inoue3 and Zhijian J. Chen. TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Nature 412, 346-351 (19 July 2001)