Reaction state_transition re11 map

p38@Cytoplasm map → p38@Cytoplasm map

Reaction regulators:
Catalysis
  1. MKK4@Cytoplasm map
  2. IRAK1:​TRAF6@Cytoplasm map
  3. MKK3@Cytoplasm map
  4. MKK6@Cytoplasm map





PMID:9162092; Deacon, K. & Blank, J. L. Characterization of the mitogen-activated protein kinase kinase 4 (MKK4)/c-Jun NH2-terminal kinase 1 and MKK3/p38 pathways regulated by MEK kinases 2 and 3. MEK kinase 3 activates MKK3 but does not cause activation of p38 kinase in vivo. J Biol Chem 272, 14489-96 (1997).
PMID:11390361. Cathy Tournier,Chen Dong, Tod K. Turner, Stephen N. Jones, Richard A. Flavell, and Roger J. Davis. MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines.
Genes Dev. 2001 June 1; 15(11): 1419–1426.
PMID:12702497.Yu Y, Zeng H, Lyons S, Carlson A, Merlin D, Neish AS, Gewirtz AT. TLR5-mediated activation of p38 MAPK regulates epithelial IL-8 expression via posttranscriptional mechanism. Am J Physiol Gastrointest Liver Physiol. 2003 Aug;285(2):G282-90. Epub 2003 Apr 17.
PMID:11323673.Hayashi F, Smith KD, Ozinsky A, Hawn TR, Yi EC, Goodlett DR, Eng JK, Akira S, Underhill DM, Aderem A.The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature. 2001 Apr 26;410(6832):1099-103.