Reaction state_transition re16 map

RIG-I@Cytoplasm map → RIG-I@Cytoplasm map

Reaction regulators:
Catalysis
  1. dsRNA@Cytoplasm map
Inhibition
  1. LGP2@Cytoplasm map
  2. DUBA@Cytoplasm map
Unknown_inhibition
  1. A20@Cytoplasm map





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PMID:16125763; Seth, R. B., Sun, L., Ea, C. K. & Chen, Z. J. Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3. Cell 122, 669-82 (2005).
PMID:16127453; Kawai, T. et al. IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nat Immunol 6, 981-8 (2005).
PMID:16838639.Kato H, Takeuchi O, Akira S.Cell type specific involvement of RIG-I in antiviral responses. Nippon Rinsho 2006 Jul;64(7):1244-7.
PMID:16306043:Lin R, Yang L, Nakhaei P, Sun Q, Sharif-Askari E, Julkunen I, Hiscott J.Negative regulation of the retinoic acid-inducible gene I-induced antiviral state by the ubiquitin-editing protein A20.J Biol Chem. 2006 Jan 27;281(4):2095-103. Epub 2005 Nov 23.
PMID:17991829; Kayagaki N, Phung Q, Chan S, Chaudhari R, Quan C, O'Rourke KM, Eby M, Pietras E, Cheng G, Bazan JF, Zhang Z, Arnott D, Dixit VM.DUBA: a deubiquitinase that regulates type I interferon production. Science. 2007 Dec 7;318(5856):1628-32. Epub 2007 Nov 8.