Reaction state_transition re50 map

MAPK7@Cytoplasm map → MAPK7@Cytoplasm map

Reaction regulators:
Catalysis
  1. TAK1 |​pho|​active@Cytoplasm map





PMID:11390361.Tournier C, Dong C, Turner TK, Jones SN, Flavell RA, Davis RJ. MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines. Genes Dev. 2001 Jun 1;15(11):1419-26.
PMID:10882101. Takaesu, G. et al. TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway. Mol. Cell 5, 649-658 (2000)
PMID:11057907.Deng, L. et al. Activation of the IkappaB kinase complex requires a dimeric ubiquitin conjugating enzyme complex and a unique polyubiquitin chain. Cell 103, 351-361 (2000).
PMID:11460167. Chen Wang1,2, Li Deng1,2, Mei Hong1, Giridhar R. Akkaraju1, Jun-ichiro Inoue3 and Zhijian J. Chen. TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Nature 412, 346-351 (19 July 2001)