Reaction state_transition re53 map

IKK1:​IKK2:​NEMO@Cytoplasm map → IKK2|​pho:​IKKE:​NEMO|​ubi@Cytoplasm map

Reaction regulators:
Catalysis
  1. PRK|​pho|​hm2:​TRAF2@Cytoplasm map
  2. TAK1 |​pho|​active@Cytoplasm map
  3. RIP1|​ubi:​TLR3:​TRIF@Endosome map
Inhibition
  1. PI3K:​TLR3|​pho:​TRIF@Endosome map





PMID:15121867. Gil J, Garcia MA, Gomez-Puertas P, Guerra S, Rullas J, Nakano H, Alcami J, Esteban M. TRAF family proteins link PKR with NF-kappa B activation.Mol Cell Biol. 2004 May;24(10):4502-12.
PMID:15064760. Meylan E, Burns K,Hofmann K, Blancheteau V,Martinon F,Kelliher M,Tschopp J.RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation.Nat Immunol. 2004 May;5(5):472-4
PMID:12471095. Yamamoto M, Sato S, Mori K, Hoshino K, Takeuchi O, Takeda K, Akira S. A novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling.Nat Immunol. 2003 Feb;4(2):105-6
PMID:11460167. Chen Wang1,2, Li Deng1,2, Mei Hong1, Giridhar R. Akkaraju1, Jun-ichiro Inoue3 and Zhijian J. Chen. TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Nature 412, 346-351 (19 July 2001)
PMID:10318845. Pullen SS, Dang TT, Crute JJ, Kehry MR.CD40 signaling through tumor necrosis factor receptor-associated factors (TRAFs). Binding site specificity and activation of downstream pathways by distinct TRAFs.
J Biol Chem. 1999 May 14;274(20):14246-54.
PMID:15670770. Chan H, Reed JC.TRAF-dependent association of protein kinase Tpl2/COT1 (MAP3K8) with CD40.
Biochem Biophys Res Commun. 2005 Mar 4;328(1):198-205.
PMID:15485931.Beinke S, Robinson MJ, Hugunin M, Ley SC.Lipopolysaccharide activation of the TPL-2/MEK/extracellular signal-regulated kinase mitogen-activated protein kinase cascade is regulated by IkappaB kinase-induced proteolysis of NF-kappaB1 p105. Mol Cell Biol. 2004 Nov;24(21):9658-67.
PMID:11297557. Salmeron A, Janzen J, Soneji Y, Bump N, Kamens J, Allen H, Ley SC.Direct phosphorylation of NF-kappaB1 p105 by the IkappaB kinase complex on serine 927 is essential for signal-induced p105 proteolysis.J Biol Chem. 2001 Jun 22;276(25):22215-22. Epub 2001 Apr 10.
PMID:15199157. Waterfield M, Jin W, Reiley W, Zhang M, Sun SC.IkappaB kinase is an essential component of the Tpl2 signaling pathway.Mol Cell Biol. 2004 Jul;24(13):6040-8.