Reaction state_transition re59 map

MDA-5@Cytoplasm map → MDA-5@Cytoplasm map

Reaction regulators:
Catalysis
  1. dsRNA@Cytoplasm map





IPS-1 /MAV associated with the CARD region of RIG-I or MDA5 through its own CARD.
PMID:16474426; Seth, R. B., Sun, L. & Chen, Z. J. Antiviral innate immunity pathways. Cell Res 16, 141-7 (2006).
PMID:16127453; Kawai, T. et al. IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nat Immunol 6, 981-8 (2005).
PMID:16125763; Seth, R. B., Sun, L., Ea, C. K. & Chen, Z. J. Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3. Cell 122, 669-82 (2005).