Reaction state_transition re64
JAK1@Cytoplasm
→ JAK1|pho@Cytoplasm
Reaction regulators:
- Catalysis
- IFNAR1:IFNAR2@Cytoplasm
- IFNGR1:IFNGR2@Cytoplasm
PMID:7673114 Kotenko SV, Izotova LS, Pollack BP, Mariano TM, Donnelly RJ, Muthukumaran G, Cook JR, Garotta G, Silvennoinen O, Ihle JN, et al. Interaction between the components of the interferon gamma receptor complex. J Biol Chem. 1995 Sep 8;270(36):20915-21.
PMID:11325598. David E. Levy and Adolfo GarcÃa-Sastreb. The virus battles: IFN induction of the antiviral state and mechanisms of viral evasion. Cytokine & Growth Factor Reviews Volume 12, Issues 2-3 , June 2001, Pages 143-156
PMID:9933596.Owen W. Nadeauab, Paul Domanskiab, Anna Usachevaac, Shahab Uddind, Leonidas C. Plataniasd, Paula Pithae, Regina Razf, David Levyf, Beata Majchrzakg, Eleanor Fishg, and Oscar R. Colamonici. The Proximal Tyrosines of the Cytoplasmic Domain of the beta Chain of the Type I Interferon Receptor Are Essential for Signal Transducer and Activator of Transcription (Stat) 2 Activation.J Biol Chem, Vol. 274, Issue 7, 4045-4052, February 12, 1999
PMID:8232552. Muller M, Briscoe J, Laxton C, Guschin D, Ziemiecki A, Silvennoinen O, Harpur AG, Barbieri G, Witthuhn BA, Schindler C, et al.The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction. Nature. 1993 Nov 11;366(6451):129-35.
PMID:18406369 Dalpke A, Heeg K, Bartz H, Baetz A. Regulation of innate immunity by suppressor of cytokine signaling (SOCS) proteins. Immunobiology. 2008;213(3-4):225-35.