Reaction state_transition re67 map

STAT2@Cytoplasm map → STAT2|​pho@Cytoplasm map

Reaction regulators:
Catalysis
  1. JAK1|​pho@Cytoplasm map
  2. TYK2|​pho@Cytoplasm map





PMID:11325598. David E. Levy and Adolfo García-Sastreb. The virus battles: IFN induction of the antiviral state and mechanisms of viral evasion. Cytokine & Growth Factor Reviews Volume 12, Issues 2-3 , June 2001, Pages 143-156
PMID:9933596.Owen W. Nadeauab, Paul Domanskiab, Anna Usachevaac, Shahab Uddind, Leonidas C. Plataniasd, Paula Pithae, Regina Razf, David Levyf, Beata Majchrzakg, Eleanor Fishg, and Oscar R. Colamonici. The Proximal Tyrosines of the Cytoplasmic Domain of the beta Chain of the Type I Interferon Receptor Are Essential for Signal Transducer and Activator of Transcription (Stat) 2 Activation.J Biol Chem, Vol. 274, Issue 7, 4045-4052, February 12, 1999
PMID:8232552. Muller M, Briscoe J, Laxton C, Guschin D, Ziemiecki A, Silvennoinen O, Harpur AG, Barbieri G, Witthuhn BA, Schindler C, et al.The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction. Nature. 1993 Nov 11;366(6451):129-35.
PMID:12804771.Takeuchi K, Kadota SI, Takeda M, Miyajima N, Nagata K.Measles virus V protein blocks interferon (IFN)-alpha/beta but not IFN-gamma signaling by inhibiting STAT1 and STAT2 phosphorylation.FEBS Lett. 2003 Jun 19;545(2-3):177-82.