Reaction state_transition re88 map

IRAK1:​IRAK4:​MYD88:​TLR8@Endosome map → IRAK1|​pho|​pho|​pho@Cytoplasm map

Reaction regulators:
Inhibition
  1. IRAK-M@Cytoplasm map





PMID:12150927.Kobayashi K, Hernandez LD, Galan JE, Janeway CA Jr, Medzhitov R, Flavell RA.IRAK-M is a negative regulator of Toll-like receptor signaling. Cell. 2002 Jul 26;110(2):191-202.
PMID:16737960.Qin J, Yao J, Cui G, Xiao H, Kim TW, Fraczek J, Wightman P, Sato S, Akira S, Puel A, Casanova JL, Su B, Li X.TLR8-mediated NF-kappaB and JNK activation are TAK1-independent and MEKK3-dependent.J Biol Chem. 2006 Jul 28;281(30):21013-21. Epub 2006 May 31.