Reaction state_transition re114 map

IKK1:​IKK2:​NEMO@Cytoplasm map → IKK1:​IKK2|​pho:​NEMO|​ubi@Cytoplasm map

Reaction regulators:
Catalysis
  1. MEKK1@Cytoplasm map
  2. NIK@Cytoplasm map
  3. MEKK3|​pho|​active@Cytoplasm map





PMID:9346485. IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK.Woronicz JD, Gao X, Cao Z, Rothe M, Goeddel DV. Science. 1997 Oct 31;278(5339):818-9.
PMID:9244310. Regnier CH, Song HY, Gao X, Goeddel DV, Cao ZD, Rothe MTitle: Identification and characterization of an I kappa B kinase.CELL 90 (2): 373-383 JUL 25 1997
PMID:9008162. Frank S. Lee, Jeremiah Hagler, Zhijian J. Chen and Tom Maniatis. Activation of the IκBα Kinase Complex by MEKK1, a Kinase of the JNK Pathway.Volume 88, Issue 2 , 24 January 1997, Pages 213-222
PMID:8898208.Liu ZG, Hsu H, Goeddel DV, Karin M.Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death. Cell. 1996 Nov 1;87(3):565-76
PMID:16260783.Blonska M, Shambharkar PB, Kobayashi M, Zhang D, Sakurai H, Su B, Lin X. TAK1 is recruited to the tumor necrosis factor-alpha (TNF-alpha) receptor 1 complex in a receptor-interacting protein (RIP)-dependent manner and cooperates with MEKK3 leading to NF-kappaB activation. J Biol Chem. 2005 Dec 30;280(52):43056-63.
PMID:9520446.Ling L, Cao Z, Goeddel DV.NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176.Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3792-7.