Reaction state_transition re165
MD2:MYD88:TIRAP:TLR4@Cytoplasm
+ IRAK4@Cytoplasm
+ IRAK1@Cytoplasm
→ IRAK1:IRAK4:MD2:MYD88:TIRAP:TLR4@Cytoplasm
No reaction regulators
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PMID:15596121.Fitzgerald KA, Rowe DC, Golenbock DT.Endotoxin recognition and signal transduction by the TLR4/MD2-complex. Microbes Infect. 2004 Dec;6(15):1361-7.
PMID:9734363. Medzhitov R, Preston-Hurlburt P, Kopp E, Stadlen A, Chen C, Ghosh S, Janeway CA Jr. MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways. Mol Cell. 1998 Aug;2(2):253-8.
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