Reaction state_transition re166 map

IRAK1:​IRAK4:​MD2:​MYD88:​TIRAP:​TLR4@Cytoplasm map → IRAK1|​pho|​pho|​pho@Cytoplasm map

Reaction regulators:
Inhibition
  1. IRAK-M@Cytoplasm map





PMID:12150927.Kobayashi K, Hernandez LD, Galan JE, Janeway CA Jr, Medzhitov R, Flavell RA.IRAK-M is a negative regulator of Toll-like receptor signaling. Cell. 2002 Jul 26;110(2):191-202.
PMID:15322147.Gohda J, Matsumura T, Inoue J. TNFR-associated factor (TRAF) 6 is essential for MyD88-dependent pathway but not toll/IL-1 receptor domain-containing adaptor-inducing IFN-beta (TRIF)- dependent pathway in TLR signaling.J Immunol. 2004 Sep 1;173(5):2913-7.
PMID:11960013.Li S, Strelow A, Fontana EJ, Wesche H.IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase.Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5567-72.
PMID:14625308.Kollewe C, Mackensen AC, Neumann D, Knop J, Cao P,Li S, Wesche H, Martin MU. Sequential autophosphorylation steps in the interleukin-1 receptor-associated kinase-1 regulate its availability as an adapter in interleukin-1 signaling.J Biol Chem. 2004 Feb 13;279(7):5227-36. Epub 2003 Nov 18.
PMID:15485931.Beinke S, Robinson MJ, Hugunin M, Ley SC.Lipopolysaccharide activation of the TPL-2/MEK/extracellular signal-regulated kinase mitogen-activated protein kinase cascade is regulated by IkappaB kinase-induced proteolysis of NF-kappaB1 p105. Mol Cell Biol. 2004 Nov;24(21):9658-67.
PMID:11297557. Salmeron A, Janzen J, Soneji Y, Bump N, Kamens J, Allen H, Ley SC.Direct phosphorylation of NF-kappaB1 p105 by the IkappaB kinase complex on serine 927 is essential for signal-induced p105 proteolysis.J Biol Chem. 2001 Jun 22;276(25):22215-22. Epub 2001 Apr 10.
PMID:15199157. Waterfield M, Jin W, Reiley W, Zhang M, Sun SC.IkappaB kinase is an essential component of the Tpl2 signaling pathway.Mol Cell Biol. 2004 Jul;24(13):6040-8.