Reaction state_transition re190
TLR2:TLR6@Cytoplasm
+ TIRAP@Cytoplasm
+ IRAK4@Cytoplasm
+ MYD88@Cytoplasm
+ IRAK1@Cytoplasm
→ IRAK1:MYD88:TIRAP:TLR2:TLR6@Cytoplasm
No reaction regulators
PMID:14977973.Okusawa T, Fujita M, Nakamura J, Into T, Yasuda M, Yoshimura A,Hara Y, Hasebe A, Golenbock DT, Morita M, Kuroki Y, Ogawa T, Shibata K.Relationship between structures and biological activities of mycoplasmal diacylated lipopeptides and their recognition by toll-like receptors 2 and 6.Infect Immun. 2004 Mar;72(3):1657-65.
PMID:12447441.Yamamoto M, Sato S, Hemmi H, Sanjo H, Uematsu S, Kaisho T, Hoshino K, Takeuchi O, Kobayashi M, Fujita T, Takeda K, Akira S.Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4. Nature. 2002 Nov 21;420(6913):324-9.
PMID:12447442.Horng T, Barton GM, Flavell RA, Medzhitov R.The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors.Nature. 2002 Nov 21;420(6913):329-33.