Reaction state_transition re211 map

TPL2 |​pho@Cytoplasm map → MEK2@Cytoplasm map

No reaction regulators




PMID:11163183. Dumitru CD, Ceci JD, Tsatsanis C, Kontoyiannis D, Stamatakis K, Lin JH, Patriotis C, Jenkins NA, Copeland NG, Kollias G, Tsichlis PN. TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway.Cell. 2000 Dec 22;103(7):1071-83.
PMID:15485931.Beinke S, Robinson MJ, Hugunin M, Ley SC.Lipopolysaccharide activation of the TPL-2/MEK/extracellular signal-regulated kinase mitogen-activated protein kinase cascade is regulated by IkappaB kinase-induced proteolysis of NF-kappaB1 p105. Mol Cell Biol. 2004 Nov;24(21):9658-67.
PMID:11297557. Salmeron A, Janzen J, Soneji Y, Bump N, Kamens J, Allen H, Ley SC.Direct phosphorylation of NF-kappaB1 p105 by the IkappaB kinase complex on serine 927 is essential for signal-induced p105 proteolysis.J Biol Chem. 2001 Jun 22;276(25):22215-22. Epub 2001 Apr 10.
PMID:15199157. Waterfield M, Jin W, Reiley W, Zhang M, Sun SC.IkappaB kinase is an essential component of the Tpl2 signaling pathway.Mol Cell Biol. 2004 Jul;24(13):6040-8.