Reaction state_transition re321 map

MDA-5@Cytoplasm map → MDA-5|​ubi|​active@Cytoplasm map

Reaction regulators:
Catalysis
  1. RNF125@Cytoplasm map





PMID:17460044. Arimoto KI, Takahashi H, Hishiki T, Konishi H, Fujita T, Shimotohno K.Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125.Proc Natl Acad Sci U S A. 2007 Apr 25
RNF125 conjugates ubiquitin to MDA5, a family protein of RIG-I, resulting in the suppression of its function.