Reaction state_transition re325 map

TRAF6|​ubi|​active@Cytoplasm map → TRAF6@Cytoplasm map

Reaction regulators:
Catalysis
  1. A20@Cytoplasm map





PMID:15258597. Wertz IE, O'Rourke KM, Zhou H, Eby M, Aravind L, Seshagiri S, Wu P, Wiesmann C, Baker R, Boone DL, Ma A, Koonin EV, Dixit VM. De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling.
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PMID:11460167. Chen Wang1,2, Li Deng1,2, Mei Hong1, Giridhar R. Akkaraju1, Jun-ichiro Inoue3 and Zhijian J. Chen. TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Nature 412, 346-351 (19 July 2001)
PMID:10882101. Takaesu, G. et al. TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway. Mol. Cell 5, 649-658 (2000)
PMID:11057907.Deng, L. et al. Activation of the IkappaB kinase complex requires a dimeric ubiquitin conjugating enzyme complex and a unique polyubiquitin chain. Cell 103, 351-361 (2000).
PMID:15334086. Boone DL, Turer EE, Lee EG, Ahmad RC, Wheeler MT, Tsui C, Hurley P, Chien M, Chai S, Hitotsumatsu O, McNally E, Pickart C, Ma A. The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses. Nat Immunol. 2004 Oct;5(10):1052-60
PMID:18268035. Turer EE, Tavares RM, Mortier E, Hitotsumatsu O, Advincula R, Lee B, Shifrin N, Malynn BA, Ma A. Homeostatic MyD88-dependent signals cause lethal inflamMation in the absence of A20. J Exp Med. 2008 Feb 18;205(2):451-64.