Reaction state_transition re336 map

dsRNA@Cytoplasm map → TAB1:​TLR3|​pho:​TRIF@Endosome map

No reaction regulators




TLR3 is phophorylated at two specific tyrosine residues at the c terminal.TAK1-TAB1-TAB2 is a preformed complex, which is recruited by TRAF6 to TLR3-TRIF complex on the membrane.
References:
PMID:12539043. Oshiumi H, Matsumoto M, Funami K, Akazawa T, Seya T.TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction.Nat Immunol. 2003 Feb;4(2):161-7. Epub 2003 Jan 21.
PMID:12855817; Yamamoto, M. et al. Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science 301, 640-3 (2003).
PMID:14982987; Jiang, Z., Mak, T. W., Sen, G. & Li, X. Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta. Proc Natl Acad Sci U S A 101, 3533-8 (2004).
PMID:12609980; Jiang, Z. et al. Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR. J Biol Chem 278, 16713-9 (2003).