Reaction heterodimer_association re654

DEPTOR@Cell membrane + Rictor:​Sin1.1:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → DEPTOR:​Rictor:​Sin1.1:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane

No reaction regulators




PMID:19446321
Loss-of-function data indicate that within cells DEPTOR is an inhibitor of mTORC1 and mTORC2 activities. However, DEPTOR overexpression led to an apparent increase instead of inhibition of mTORC2 signaling as monitored by Akt S473 phosphorylation (Figure 5C and S4).
The authors propose that the effects of DEPTOR overexpression on the mTOR pathway-inhibition of mTORC1 signaling but apparent activation of mTORC2 signaling-result from DEPTOR-mediated inhibition of mTORC1, which then leads to the hyperactivation of PI3K that would overcome the direct inhibitory
effects of DEPTOR on mTORC2.