Reaction state_transition re293 
Mnk1/2:eIF4E:eIF4G|S1108_pho|S1148_pho|S1192_pho:m7GTP:mRNA@Cell membrane → Mnk1/2:eIF4E|S209_pho:eIF4G|S1108_pho|S1148_pho|S1192_pho:m7GTP:mRNA@Cell membrane
Reaction regulators:
- Catalysis
- Mnk1/2:eIF4E:eIF4G|S1108_pho|S1148_pho|S1192_pho:m7GTP:mRNA@Cell membrane
PMID:9878069
PMID:15254222
The biological function of eIF4E phosphorylation has been contreversial. Some studies report that eIF4E Ser209 phosphorylation enhance translation in general, while others conclude that Ser209 has no effect, or even reduces translation.
Recently, Ser209 phosphorylation site has been reported essential for
eIF4E's oncogenic action in mice.
PMID:2318815
PMID:2105935
PMID:9654048
PMID:11368785
PMID:11606200
PMID:11723111
PMID:18055695