Reaction heterodimer_association re314 map

PABP:​eIF3:​eIF4A:​eIF4B|​S422_pho:​eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane map + GDP:​eIF2_alpha:​eIF2_beta:​eIF2_gamma:​eIF3:​rpS6/40S subunit|​S235_pho|​S236_pho|​S240_pho|​S244_pho|​S247_pho@Cell membrane map → 5'cap-eIF4F-eIF4B-eIF3-PABP:​eIF2-GTP_Met-tRNAi_40S@Cell membrane map

No reaction regulators




From Proud, 2007 (PMID:17376031) Mammalian eIF3 possesses 12 subunits and binds to the ribosome's 40S subunit.
It thus provies a key link between the mRNA (which binds via eIF4E, PABP and other ineractions to eIF4G and its partners) and the 40S subunit.