Protein EGLN1 map

Identifiers
HUGO:EGLN1

Maps_Modules
 MACROPHAGE  map
MODULE:IMMUNOSUPPPRESSIVE_CORE_PATHWAYS
MODULE:MIRNA_TF_IMMUNOSUPPRESSIVE

References
PMID:21765015
The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. EGLN1@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
      As Catalyser:
      1. HIF1A@INNATE_IMMUNE_CELL_Cytosol map → map degraded