Protein HIF1A map

Identifiers
HUGO:HIF1A

Maps_Modules
MODULE:IMMUNOSUPPPRESSIVE_CORE_PATHWAYS MODULE:MIRNA_TF_IMMUNOSUPPRESSIVE

References
 NATURAL_KILLER  map
 MACROPHAGE  map
CASCADE:IL4
CASCADE:LACTIC
CASCADE:IL13
CASCADE:CSF2
CASCADE:IFNG
PMID:22006996
Hypoxia-induced expression of ADAM10 is HIF-1-dependent.
PMID:25103413
Hypoxia downregulates MICA, MICB surface expression via HIF1A.
PMID:24006507
HIF1A expression is assotiated with classical activation of macrophages
PMID:20427344
HIF1 expression is assotiated with classical activation of macrophages
HIF1A upregulates expression of: TNF, IL6, HIF1A downregulates expression of M2 markers CD206 and STAB1.
PMID_24006507
IL4 downregulates HIF1a translation.
PMID:21765015
CSF2 upregulates VEGF expression via HIF1a specific inhibition of PHD2 increases VEGF production
HIF1a induces MIF expression of macrophages after hypoxia.
IL4+IL13 inhibit MIF expression via inhibition of HIF1a expression.
PMID:16127144
HIF-1A and HIF-2A are up-regulated by human macrophages exposed to hypoxia in vitro and by TAMs in hypoxic/necrotic areas of human tumors.
PMID:25043024
Lactic acid is sufficient to induce Vegf and Arg1 via HIF1α.
Lactic acid, probably via HIF1A polarizes macrophages to an M2-Iike state that is critical for tumour growth
HIF1A upregulates expression of: TNF, IL6 and downregulates expression of M2 markers CD206 and STAB1
HIF1A upregulates expression of EGLN1, EGLN3, PDK1, Pfkfb3, GLUT1, VEGF, FGF2 Mif, Ccr2, Cxcl2


Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. HIF1A@INNATE_IMMUNE_CELL_Cytosol map
In compartment: TUMOR_CELL_AS_INDUCTOR
  1. HIF1A@TUMOR_CELL_AS_INDUCTOR map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. HIF1A@TUMOR_CELL_AS_INDUCTOR map map degraded
    2. HIF1A@TUMOR_CELL_AS_INDUCTOR map map HIF1A@TUMOR_CELL_AS_INDUCTOR map
    3. rHIF1A@INNATE_IMMUNE_CELL_Cytosol map map HIF1A@INNATE_IMMUNE_CELL_Cytosol map
    4. HIF1A@INNATE_IMMUNE_CELL_Cytosol map map HIF1A@INNATE_IMMUNE_CELL_Cytosol map
    5. HIF1A@INNATE_IMMUNE_CELL_Cytosol map map degraded
    As Catalyser:
    1. gTNF@INNATE_IMMUNE_CELL_Cytosol map map rTNF@INNATE_IMMUNE_CELL_Cytosol map
    2. gMIF@INNATE_IMMUNE_CELL_Cytosol map map rMIF@INNATE_IMMUNE_CELL_Cytosol map
    3. gMICB@TUMOR_CELL_AS_INDUCTOR map map rMICB@TUMOR_CELL_AS_INDUCTOR map
    4. gADAM10@TUMOR_CELL_AS_INDUCTOR map map rADAM10@TUMOR_CELL_AS_INDUCTOR map
    5. gARG1@INNATE_IMMUNE_CELL_Cytosol map map rARG1@INNATE_IMMUNE_CELL_Cytosol map
    6. gIL6@INNATE_IMMUNE_CELL_Cytosol map map rIL6@INNATE_IMMUNE_CELL_Cytosol map
    7. gVEGFA@INNATE_IMMUNE_CELL_Cytosol map map rVEGFA@INNATE_IMMUNE_CELL_Cytosol map