Identifiers
HUGO:HIF1A
Maps_Modules
MODULE:IMMUNOSUPPPRESSIVE_CORE_PATHWAYS MODULE:MIRNA_TF_IMMUNOSUPPRESSIVE
References
NATURAL_KILLER
MACROPHAGE
CASCADE:IL4
CASCADE:LACTIC
CASCADE:IL13
CASCADE:CSF2
CASCADE:IFNG
PMID:22006996
Hypoxia-induced expression of ADAM10 is HIF-1-dependent.
PMID:25103413
Hypoxia downregulates MICA, MICB surface expression via HIF1A.
PMID:24006507
HIF1A expression is assotiated with classical activation of macrophages
PMID:20427344
HIF1 expression is assotiated with classical activation of macrophages
HIF1A upregulates expression of: TNF, IL6, HIF1A downregulates expression of M2 markers CD206 and STAB1.
PMID_24006507
IL4 downregulates HIF1a translation.
PMID:21765015
CSF2 upregulates VEGF expression via HIF1a specific inhibition of PHD2 increases VEGF production
HIF1a induces MIF expression of macrophages after hypoxia.
IL4+IL13 inhibit MIF expression via inhibition of HIF1a expression.
PMID:16127144
HIF-1A and HIF-2A are up-regulated by human macrophages exposed to hypoxia in vitro and by TAMs in hypoxic/necrotic areas of human tumors.
PMID:25043024
Lactic acid is sufficient to induce Vegf and Arg1 via HIF1α.
Lactic acid, probably via HIF1A polarizes macrophages to an M2-Iike state that is critical for tumour growth
HIF1A upregulates expression of: TNF, IL6 and downregulates expression of M2 markers CD206 and STAB1
HIF1A upregulates expression of EGLN1, EGLN3, PDK1, Pfkfb3, GLUT1, VEGF, FGF2 Mif, Ccr2, Cxcl2