Protein PLA2G4A map

Identifiers
HUGO:PLA2G4A

Maps_Modules
MODULE:CORE_SIGNALING_PATHWAYS MODULE:IMMUNOSTIMULATORY_CORE_PATHWAYS

References
 NATURAL_KILLER  map
CASCADE:Fc_gamma_RIII
PMID:9120268, PMID:9973479
ERK2 activates Phospholipase A2 group IIA (sPLA2 and cPLA2) by phosphorylation downstream of CD16 activation, but CDl6-induced degranulation in human NK cells is
dependent on ERK activation, but not on sPLA, or cPLA.
PMID:8388321
Arachidonic acid (AA) release via phospholipase A2 (PLA2) activation has positive influence on both NK and ADCC activities of natural killers.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. PLA2G4A@INNATE_IMMUNE_CELL_Cytosol map
  2. PLA2G4A|​pho@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. PLA2G4A@INNATE_IMMUNE_CELL_Cytosol map → map PLA2G4A|​pho@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser: