Identifiers
HUGO:CXCL12
CASCADE:PGE2
CASCADE:CXCL12
Maps_Modules
MACROPHAGE
MDSC
DENDRITIC_CELL
MODULE:RECRUITMENT_OF_IMMUNE_CELLS
References
PMID:20644254
CXCR4, the receptor for the chemokine CXCL12 (also known as SDF-1), also plays an important role in facilitating macrophage migration in vivo.
PMID:22025564
PGE(2) was essential both for expression of functional CXCR4 in cancer-associated MDSCs and for production of its ligand CXCL12 by tumor cells. Frequencies of CD11b(+)CD14(+)CD33(+)CXCR4(+) MDSCs closely correlated with CXCL12 and PGE(2) levels in patient ascites. MDSCs migrated toward ovarian cancer ascites in a CXCR4-dependent manner that required COX2 activity and autocrine PGE(2) production.
PMID:17035340
The secretion of HMGB1 is required for the migration of maturing dendritic cells.
myeloid DC, which rapidly secrete upon maturation induction their own HMGB1, remodel their actin-based cytoskeleton, up-regulate the CCR7 and the CXCR4 chemokine receptors, and acquire the ability to migrate in response to chemokine receptor ligands. The events are apparently causally related: DC challenged with LPS in the presence of HMGB1-specific antibodies fail to up-regulate the expression of the CCR7 and CXCR4 receptors and to rearrange actin-rich structures. Moreover, DC matured in the presence of anti-HMGB1 antibodies fail to migrate in response to the CCR7 ligand CCL19 and to the CXCR4 ligand CXCL12
→ CXCL12@default
→ RECRUITMENT_OF_IMMUNE_CELLS@INNATE_IMMUNE_CELL_Cytosol
+ CXCR4@INNATE_IMMUNE_CELL_Membrane → CXCL12:CXCR4@INNATE_IMMUNE_CELL_Membrane