Protein HRAS map

Identifiers
HUGO:HRAS

Maps_Modules
MODULE:CORE_SIGNALING_PATHWAYS MODULE:IMMUNOSTIMULATORY_CORE_PATHWAYS

References
 NATURAL_KILLER  map
CASCADE:Fc_gamma_RIII
PMID:8551221, PMID:10358164
CD16 and IL-2R Triggering Activate p21RAS in Human NK Cells via LAT/SHC/GRB2/sos pathway.
Phosphorylated Shc interacts with Grb2, which, in turn, interacts with Sos.
PMID:9763606
Cross-linking of β1 Integrins on Human NK Cells Induces Shc Tyrosine Phosphorylation and Grb2 Association via Pyk-2end
resulted in RAS/ERK activation.

Modifications:
In compartment: PHAGOSOME/ENDOSOME/LYSOSOME_Membrane
  1. HRAS@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. GDP:​HRAS@INNATE_IMMUNE_CELL_Cytosol map
  2. GTP:​HRAS@INNATE_IMMUNE_CELL_Cytosol map
Participates in reactions:
As Reactant or Product:
  1. GDP:​HRAS@INNATE_IMMUNE_CELL_Cytosol map + GTP@INNATE_IMMUNE_CELL_Cytosol map → map GTP:​HRAS@INNATE_IMMUNE_CELL_Cytosol map + GDP@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser:
  1. Tumor_antigen@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map → map Tumor_antigen_fragment@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map
  2. RAF1@INNATE_IMMUNE_CELL_Cytosol map → map RAF1|​pho@INNATE_IMMUNE_CELL_Cytosol map