Protein RAF1
Identifiers
HUGO:RAF1
Maps_Modules
MODULE:CORE_SIGNALING_PATHWAYS MODULE:IMMUNOSTIMULATORY_CORE_PATHWAYS
References
NATURAL_KILLER
PMID:15516985, PMID:12566895
HRAS activates MEK/ERK pathway via RAF phosphorylation in NK cells.
Ras functions asan adapter that binds to Raf kinases.
Raf can activate both MEK1 and MEK2 (also called MKK1 and MKK2)
Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
- RAF1@INNATE_IMMUNE_CELL_Cytosol
- RAF1|pho@INNATE_IMMUNE_CELL_Cytosol
Participates in complexes:
Participates in reactions:
As Reactant or Product:- RAF1@INNATE_IMMUNE_CELL_Cytosol
→
RAF1|pho@INNATE_IMMUNE_CELL_Cytosol
As Catalyser:- MEK*@INNATE_IMMUNE_CELL_Cytosol
→
MEK*|pho@INNATE_IMMUNE_CELL_Cytosol