Protein LGALS3 map

Identifiers
HUGO:LGALS3

Maps_Modules
 MACROPHAGE  map
MODULE:MARKERS_MACROPHAGE
MODULE:INPUT_INHIBITORS
MODULE:IMMUNE_SUPPRESSION
MODULE:IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS
MODULE:EFFECTOR_INHIBITION
MODULE:IMMUNOSUPPRESSIVE_CYTOKINE_EXPRESSION
CASCADE:LGALS3
CASCADE:TGFB
CASCADE:IL4
CASCADE:IL13

References
PMID:22703233
TGFBR2 upregulates expression of markers M2 activation as ARG1, MCR2 and LGALS3 (galecsin3) and induces AKT activation.
PMID:18250477
LGALS3 participates in M2 activation of macrophages. And vice versa classically activated macrophages down-regulate galectin-3 expression and show reduced galectin-3 expression on the cell surface.
IL-4 or IL-13 stimulated the release of galectin-3
into the culture media in both BMDMs and PBMs.
An IL-4-mediated LGALS3 (galectin-3) autocrine loop promotes alternative macrophage activation and is blocked by pharmacological inhibition of galectin-3 and its receptor CD98.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. LGALS3@INNATE_IMMUNE_CELL_Cytosol map
In compartment: MARKERS_MACROPHAGE
  1. LGALS3@MARKERS_MACROPHAGE map
In compartment: default
  1. LGALS3@default map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. LGALS3:​SLC3A2@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. rLGALS3@INNATE_IMMUNE_CELL_Cytosol map → map LGALS3@INNATE_IMMUNE_CELL_Cytosol map
  2. LGALS3@INNATE_IMMUNE_CELL_Cytosol map → map LGALS3@default map
  3. LGALS3@INNATE_IMMUNE_CELL_Cytosol map → map IMMUNE_SUPRESSION@default map
  4. LGALS3@default map + SLC3A2@INNATE_IMMUNE_CELL_Membrane map → map LGALS3:​SLC3A2@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. PI3KR(p85)*@INNATE_IMMUNE_CELL_Cytosol map → map PI3KR(p85)*@INNATE_IMMUNE_CELL_Cytosol map