Protein RHOA map

Identifiers
HUGO:RHOA

Maps_Modules
MODULE:CORE_SIGNALING_PATHWAYS MODULE:IMMUNOSTIMULATORY_CORE_PATHWAYS

References
CASCADE:CR3
 NATURAL_KILLER  map
 MACROPHAGE  map
PMID:12740575
VAV1 activates RHOA and RAC1 downstream of NKG2D.
PMID:11698448
RHOA signaling in NK cells provides development of natural cytotoxicity against tumor cells.
PMID:12194823
Rho-kinase and myosin-II control phagocytic cup formation during CR3, but not FcgammaR, phagocytosis.
inhibition of the Rho --> ROK --> myosin-II pathway caused a decreased accumulation of Arp2/3 complex and F-actin around bound particles, which led to a reduction in CR-mediated phagocytic engulfment. FcgammaR-mediated phagocytosis, in contrast, was independent of Rho or ROK activity and was only dependent on myosin-II for particle internalization, not for actin cup formation. While myosins have been previously implicated in FcgammaR phagocytosis, to our knowledge, this is the first demonstration of a role for myosin-II in CR phagocytosis.

Modifications:
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. GDP:​RHOA@INNATE_IMMUNE_CELL_Cytosol map
  2. (GTP:​RHOA)|​active@INNATE_IMMUNE_CELL_Cytosol map
Participates in reactions:
As Reactant or Product:
  1. GDP:​RHOA@INNATE_IMMUNE_CELL_Cytosol map + GTP@INNATE_IMMUNE_CELL_Cytosol map → map (GTP:​RHOA)|​active@INNATE_IMMUNE_CELL_Cytosol map + GDP@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser:
  1. ROCK1@INNATE_IMMUNE_CELL_Cytosol map → map ROCK1@INNATE_IMMUNE_CELL_Cytosol map