Protein ROCK1 map

Identifiers
HUGO:ROCK1

Maps_Modules
MODULE:CORE_SIGNALING_PATHWAYS MODULE:IMMUNOSTIMULATORY_CORE_PATHWAYS

References
 NATURAL_KILLER  map
 MACROPHAGE  map
CASCADE:CR3
PMID:12778124
The kinase activity of ROCKs is moderately enhanced after Rho binding.
PMID:11698448
p160ROCK plays a fundamental role in the development of cellular cytotoxicity via LIMK1 phosphorylation. But it does not affect conjugate formation.
PMID:12194823
Rho-kinase and myosin-II control phagocytic cup formation during CR3, but not FcgammaR, phagocytosis.
inhibition of the Rho --> ROK --> myosin-II pathway caused a decreased accumulation of Arp2/3 complex and F-actin around bound particles, which led to a reduction in CR-mediated phagocytic engulfment. FcgammaR-mediated phagocytosis, in contrast, was independent of Rho or ROK activity and was only dependent on myosin-II for particle internalization, not for actin cup formation. While myosins have been previously implicated in FcgammaR phagocytosis, to our knowledge, this is the first demonstration of a role for myosin-II in CR phagocytosis.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. ROCK1@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. ROCK1@INNATE_IMMUNE_CELL_Cytosol map → map ROCK1@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser:
    1. LIMK1@INNATE_IMMUNE_CELL_Cytosol map → map LIMK1|​pho@INNATE_IMMUNE_CELL_Cytosol map
    2. ELC_MYOSIN_II*:​MYH9|​hm2:​RLC_MYOSIN_II*@INNATE_IMMUNE_CELL_Cytosol map → map ELC_MYOSIN_II*:​MYH9|​hm2:​RLC_MYOSIN_II*|​pho@INNATE_IMMUNE_CELL_Cytosol map