Protein PDL1* map

Identifiers
HUGO:CD274

Maps_Modules
MODULE:IMMUNOSUPPRESSIVE_CHEKPOINTS MODULE:IMMUNE_SUPPRESSION MODULE:EFFECTOR_INHIBITION

References
 DENDRITIC_CELL  map
PMID:24076050, PMID:12538684
PDL1 and PDL2 are expressed in DCs.
blockade of PD-L2 on dendritic cells results in enhanced T cell proliferation and cytokine production, including that of IFN-gamma and IL-10, while blockade of PD-L1 results in similar, more modest, effects. Blockade of both PD-L1 and PD-L2 showed an additive effect. Both whole mAb and Fab enhanced T cell activation, showing that PD-L1 and PD-L2 function to inhibit T cell activation.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. PDL1*@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. PDL1*@INNATE_IMMUNE_CELL_Cytosol map → map Immune_checkpoints_T_cells_Inhibitors@INNATE_IMMUNE_CELL_Membrane map
    As Catalyser: