Identifiers
HUGO:MYC
Maps_Modules
MACROPHAGE
MDSC
NEUTROPHIL
MODULE:CORE_SIGNALING_PATHWAYS
MODULE:MIRNA_TF_IMMUNOSUPPRESSIVE
CASCADE:GSF3
CASCADE:IL4
CASCADE:IFNAB
References
PMID:22067385
c-MYC expression is assosiated with M2 type of macrophages.
IL4 induces MYC expression in macrophages. MYC directly regulates some genes associated with alternative activation, including SCARB1, ALOX15, and MRC1, whereas others, including CD209, are indirectly regulated by c-MYC. c-MYC up-regulates the IL-4 signaling mediators signal transducer and activator of transcription-6 and peroxisome proliferator-activated receptorγ, is also expressed in tumor-associated macrophages, and its inhibition blocks the expression of protumoral genes including VEGF, MMP9, HIF-1A, and TGFB.
PMID:20581311
STAT3 as an essential mediator of emergency granulopoiesis by its regulation of transcription factors that direct G-CSF-responsive myeloid progenitor expansion.
STAT3 directly controls G-CSF-dependent expression of CCAAT-enhancer-binding protein β (C/EBPβ), a crucial factor in the emergency granulopoiesis response. Moreover, STAT3 and C/EBPβ coregulate c-Myc through interactions with the c-myc promoter that control the duration of C/EBPα occupancy during demand-driven granulopoiesis.
→ rMYC@INNATE_IMMUNE_CELL_Cytosol
→ MYC@INNATE_IMMUNE_CELL_Cytosol