Protein RBCK1 map

Identifiers
HUGO:RBCK1

Maps_Modules
 MACROPHAGE  map
MODULE:INPUT_ACTIVATORS
MODULE:IMMUNE_STIMULATION
MODULE:IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS
CASCADE:TNF

References
PMID:24699077
LUBAC, linear ubiquitin chain assembly complex comprises  SHANK-associated RH-domain interactor (SHARPIN), heme-oxidized IRP2 ubiquitin ligase 1 homolog (HOIL1/RBCK1) and the E3 HOIL-1–interacting protein (HOIP/RNF31)
—is recruited to the TNFR1 complex via binding to the autoubiquitinated c-IAP1 and c-IAP2 proteins to mediate the assembly of linear polyubiquitin chains on NF-κB essential modifier (NEMO/IKBKG) and RIPK1

Modifications:
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. RBCK1:​RNF31:​SHARPIN@INNATE_IMMUNE_CELL_Cytosol map
Participates in reactions:
As Reactant or Product:
    As Catalyser:
    1. IKBKG:​IKK_alpha_*:​IKK_beta_*@INNATE_IMMUNE_CELL_Cytosol map → map IKBKG|​ubi:​IKK_beta_*|​pho:​MHC_class_I*@INNATE_IMMUNE_CELL_Cytosol map