IKBKG:IKK_alpha_*:IKK_beta

Complex IKBKG:IKK_alpha_*:IKK_beta_*

Complex composition:

IKBKG|ubi:IKK_beta_*|pho:MHC_class_I*@INNATE_IMMUNE_CELL_Cytosol

Identifiers
NAME:IKBKG:IKK_beta_*:MHC_class_I*

Maps_Modules
DENDRITIC_CELL
MACROPHAGE
MDSC
MODULE:CORE_SIGNALING_PATHWAYS
MODULE:IMMUNOSTIMULATORY_CORE_PATHWAYS
CASCADE:IL13
CASCADE:VEGFA
CASCADE:STING
CASCADE:TLR2_4
CASCADE:IL2
CASCADE:CSF2
CASCADE:TNF

References
complex
PMID‭:15145317, PMID:15573129
The activated IKK complex,
catalyzes the phosphorylation of IkBs (at sites
equivalent to Ser32 and Ser36 of IkBa), polyubiquitination
(at sites equivalent to Lys21 and Lys22 of IkBa) and
subsequent degradation by the 26S proteasome. The
released NF-kB dimers (in this pathway, most commonly
the p50– RelA dimer) translocate to the nucleus, bind DNA
and activate gene transcription
PMID:15573129
NF-B is required for the development of DCs
Blocking NF-B activity been shown to prevent DC differentiation from progenitor cells in vitro.
PMID:24766893
Cytosolic DNA induces type I IFNs through the endoplasmic reticulum membrane protein STING, which subsequently activates the transcription factors NF-κB and IRF3 through the kinases IKK and TBK1, respectively
PMID:11438547, PMID:24378531
in macrophages
Both TNFR1 and TNFR2 signaling pathways induce classical NFkB activation via IKBa degradation.
Both TNFR1 and TNFR2 signaling pathways induce JNK activation and downstrean c-jun phosphorylation.
Both TNFR1 and TNFR2 signaling pathways are needed for activation of p38 MAPK.

IKBKG:IKK_alpha_*:IKK_beta_*@INNATE_IMMUNE_CELL_Cytosol

Identifiers
NAME:IKBKG:IKK_alpha_*:IKK_beta_*

Maps_Modules
MACROPHAGE
MDSC
MODULE:CORE_SIGNALING_PATHWAYS
MODULE:IMMUNOSTIMULATORY_CORE_PATHWAYS
CASCADE:IL13
CASCADE:VEGFA
CASCADE:STING
CASCADE:TLR2_4
CASCADE:IL2
CASCADE:CSF2
CASCADE:TNF

References
complex
PMID‭:15145317
The activated IKK complex,
catalyzes the phosphorylation of IkBs (at sites
equivalent to Ser32 and Ser36 of IkBa), polyubiquitination
(at sites equivalent to Lys21 and Lys22 of IkBa) and
subsequent degradation by the 26S proteasome. The
released NF-kB dimers (in this pathway, most commonly
the p50– RelA dimer) translocate to the nucleus, bind DNA
and activate gene transcription
PMID:10521409, PMID:18802069
The endogenous IKK complex, overexpressed IKKs, and recombinant IKKbeta efficiently phosphorylated the Ser536 residue of p65 in vivo and in vitro,
that is important foe NFKB signaling activation.Ser536 is phoshorylated downstream of RAGE signaling in MDSC.
PMID:24766893
Cytosolic DNA induces type I IFNs through the endoplasmic reticulum membrane protein STING, which subsequently activates the transcription factors NF-κB and IRF3 through the kinases IKK and TBK1, respectively

Modifications:
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol

Participates in reactions:
As Reactant or Product:

As Catalyser: