Protein MSR1 map

Identifiers
HUGO:MSR1

References
 DENDRITIC_CELL  map
CASCADE:MSR1
PMID:12594251
Dendritic cells can capture the antigens through the ‘nibbling’ of live tumour cells, Class A Scavenger Receptor (MSR1) regulates the process.
Internalized membrane colocalized with SR ligand and entered the endosomal pathway.
DC very efficiently acquired and internalized gp100 tumor Ag expressed at the surface of viable adenocarcinoma cells via recombinant adenoviral infection. Cross-presentation of gp100 by DC to MHC class I-restricted T cells was inhibited by polyanionic SR ligand and an Ab to type A SR (SR-A), whereas Ab to the class B SR CD36, which mediates uptake of apoptotic cells, induced no inhibition.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. MSR1@INNATE_IMMUNE_CELL_Membrane map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
      As Catalyser:
      1. Tumor_antigen@TUMOR_CELL_AS_EFFECTOR map → map Tumor_antigen@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map