Reaction state_transition re1 map

Tumor_antigen@TUMOR_CELL_AS_EFFECTOR map → Tumor_antigen@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map

Reaction regulators:
Catalysis
  1. MSR1@INNATE_IMMUNE_CELL_Membrane map
  2. ITGAV:​ITGB3:​MFGE8:​PtdSer@INNATE_IMMUNE_CELL_Membrane map
  3. ITGAV:​ITGB5:​MFGE8@INNATE_IMMUNE_CELL_Membrane map
  4. CD36:​oxPS@INNATE_IMMUNE_CELL_Membrane map
  5. EXOCYTOSIS_AND_PHAGOCYTOSIS@INNATE_IMMUNE_CELL_Membrane map
  6. Ca2+@INNATE_IMMUNE_CELL_Cytosol map





References
PMID:10837075
Immature DCs are very efficient in Ag capture and can use several pathways, such as (a) macropinocytosis; (b) receptor-mediated endocytosis via C-type lectin receptors (mannose receptor, DEC-205)
or Fcγ receptor types I (CD64) and II (CD32) [uptake of immune complexes or opsonized particles ]; and (c) phagocytosis of particles such as latex beads , apoptotic and necrotic cell fragments (involving CD36 and αvβ3 or αvβ5 integrins), viruses, and bacteria including mycobacteria, as well as intracellular parasites such as Leishmania major. DCs can also internalize the peptide loaded heat shock proteins gp96 and Hsp70 through presently unknown mechanisms