Protein MARCH1 map

Identifiers
HUGO:MARCH1

Maps_Modules
MODULE:IMMUNE_STIMULATION MODULE:IMMUNOSTIMULATORY_CHEKPOINTS MODULE:ANTIGEN_PRESENTATION MODULE:EFFECTOR_ACTIVATION

References
 DENDRITIC_CELL  map
CASCADE:IL10
PMID:22076556, PMID:21220452, PMID:24218453
CD83 increases MHC II and CD86 on dendritic cells by opposing IL-10-driven MARCH1-mediated ubiquitination and degradation.
T regulatory cells impair dendritic cell function via an IL-10/MARCH1-dependent mechanism.
Both the enhanced expression of MARCH1 and the decreased expression of CD83 were mediated by IL-10 produced by the iTregs.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. MARCH1@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. rMARCH1@INNATE_IMMUNE_CELL_Cytosol map → map MARCH1@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser:
    1. MHC_class_II*:​Tumor_antigen_fragment@INNATE_IMMUNE_CELL_Membrane map → map MHC_class_II*|​ubi:​Tumor_antigen_fragment@INNATE_IMMUNE_CELL_Cytosol map
    2. CD86@INNATE_IMMUNE_CELL_Membrane map → map CD86|​ubi@INNATE_IMMUNE_CELL_Membrane map