Protein PTPN2 map

Identifiers
HUGO:PTPN2

Maps_Modules
 MACROPHAGE  map
MODULE:INPUT_ACTIVATORS
MODULE:IMMUNE_STIMULATION
MODULE:IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS

References
PMID:19833085, PMID:15699106, PMID:12138178
Inactivation of nuclear STAT1 occurs rapidly following binding to chromatin and activation of target gene transcription.
Subsequently STAT1 is dephosphorylated by phosphatases such as PTPN2 (TCP45) and PTPN11 (SHP2), and dephosphorylated STAT1
returns to cytoplasm, where it can potentially serve as the substrate for subsequent rounds of activation and inactivation.
PMID:19833085
Probably, acetylation of STAT1 on lysine residues 410 and 413 in the nucleus results in enhanced interaction with TCP45 (PTPN2) and increased dephosphorylation

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. PTPN2@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
      As Catalyser:
      1. STAT1|​pho|​ace@INNATE_IMMUNE_CELL_Cytosol map → map STAT1|​ace@INNATE_IMMUNE_CELL_Cytosol map
      2. STAT1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map → map STAT1@INNATE_IMMUNE_CELL_Cytosol map