Protein STAT1 map

Identifiers
HUGO:STAT1

Maps_Modules
 MACROPHAGE  map
 DENDRITIC_CELL  map
 NATURAL_KILLER  map
 MDSC  map
MODULE:INPUT_INHIBITORS
MODULE:IMMUNE_SUPPRESSION
MODULE:IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS
MODULE:INPUT_ACTIVATORS
MODULE:IMMUNE_STIMULATION
MODULE:IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS
CASCADE:IL13
CASCADE:IL15
CASCADE:IL21
CASCADE:SCF2
CASCADE:IFNAB

References
PMID:12223527
Stat proteins 1 alpha, 3, 5A, 5B, and 6 are phosphorylated in response to IL-13.
PMID:19833085
STAT1 is activated downstream of IFNG by phosphorylation of tyrosine 701, translocates to the nucleus, binds to a regulatory DNA element termed gamma-activated sequence (GAS) and stimulates transcription of STAT1 target genes.
PMID:17689680
STAT1 acetilation inhibits its activity in macrophages.
PMID:12811837
TLR signaling can induces STAT1 phosphorylation via p38 and potentiate IFNG signaling.
PMID:14607900
FNG inhibits IL10 signalind via STAT1.
STAT1 overexpression prevents STAT3 homodimerization.
PMID:12193701, PMID:11830590
CD40 expression is upregulated by STAT1 downstream of INFG
and NF-kB downstream of TNF.
PMID:12193701
INFG upregulates TNFR1 and PIPK1 expression, probably via JAK/STAT1 pathway
because this expression is inhibited in presense of SOCS1.
PMID:15814715, PMID:18272812, PMID:17016554
STAT1 is involeved in immunosupresive activity of M2 macrophages and MDSC, probably downstream of IFNG.
PMID:21930765, PMID:8683106, PMID:12967644
IFNA and IFNB act via STAT1 pathway in DC and NK cells
PMID:25960930
Reduced IFNα-induced STAT-1 phosphorylation in Ser727 and CXCL10 secretion in NK cells derived from PKC-θ−/− mice
 11207245
I IFN receptor signaling regulates antigen cross-presentation to CD8(+) T cells. (), probably via upregulation of CD80, CD86, CD40, CD83 and MHC class II and CD11c,
PMID:17513775
Probably via STAT1(demondrtated for CD40 and CD11c PMID:14764699, and for CD40, CD80, CD86, and MHC II 

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. STAT1@INNATE_IMMUNE_CELL_Cytosol map
  2. STAT1|​ace@INNATE_IMMUNE_CELL_Cytosol map
  3. STAT1|​pho|​ace@INNATE_IMMUNE_CELL_Cytosol map
  4. STAT1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. STAT1|​pho:​TNFR1*@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. STAT1@INNATE_IMMUNE_CELL_Cytosol map → map STAT1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  2. STAT1@INNATE_IMMUNE_CELL_Cytosol map → map STAT1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  3. STAT1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map → map STAT1|​pho|​ace@INNATE_IMMUNE_CELL_Cytosol map
  4. STAT1|​pho|​ace@INNATE_IMMUNE_CELL_Cytosol map → map STAT1|​ace@INNATE_IMMUNE_CELL_Cytosol map
  5. STAT1|​ace@INNATE_IMMUNE_CELL_Cytosol map → map STAT1@INNATE_IMMUNE_CELL_Cytosol map
  6. STAT1|​pho|​ace@INNATE_IMMUNE_CELL_Cytosol map → map STAT1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  7. STAT1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map → map STAT1@INNATE_IMMUNE_CELL_Cytosol map
  8. STAT1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map + TNFR1*@INNATE_IMMUNE_CELL_Membrane map → map STAT1|​pho:​TNFR1*@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. gTNF@INNATE_IMMUNE_CELL_Cytosol map → map rTNF@INNATE_IMMUNE_CELL_Cytosol map
  2. gTBX21@INNATE_IMMUNE_CELL_Cytosol map → map rTBX21@INNATE_IMMUNE_CELL_Cytosol map
  3. gMAOA@INNATE_IMMUNE_CELL_Cytosol map → map rMAOA@INNATE_IMMUNE_CELL_Cytosol map
  4. CCL2@INNATE_IMMUNE_CELL_Cytosol map → map CCL2@default map
  5. rCD11c*@MARKERS_DC map → map CD11c*@MARKERS_DC map
  6. gIDO1@INNATE_IMMUNE_CELL_Cytosol map → map rIDO1@INNATE_IMMUNE_CELL_Cytosol map
  7. CD40@INNATE_IMMUNE_CELL_Cytosol map → map CD40@INNATE_IMMUNE_CELL_Membrane map
  8. CD80@INNATE_IMMUNE_CELL_Cytosol map → map CD80@INNATE_IMMUNE_CELL_Membrane map
  9. CD86@INNATE_IMMUNE_CELL_Cytosol map → map CD86@INNATE_IMMUNE_CELL_Membrane map
  10. STAT3|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map → map STAT3|​pho|​hm2|​active@INNATE_IMMUNE_CELL_Cytosol map
  11. gNOS2@INNATE_IMMUNE_CELL_Cytosol map → map rNOS2@INNATE_IMMUNE_CELL_Cytosol map
  12. CD74:​MHC_class_II*@Endoplasmic Reticulum_Membrane map → map CD74:​MHC_class_II*@INNATE_IMMUNE_CELL_Membrane map
  13. gMHC class I*@INNATE_IMMUNE_CELL_Cytosol map → map rMHC class I*@INNATE_IMMUNE_CELL_Cytosol map
  14. gCIITA@INNATE_IMMUNE_CELL_Cytosol map → map rCIITA@INNATE_IMMUNE_CELL_Cytosol map
  15. gMYD88@INNATE_IMMUNE_CELL_Cytosol map → map rMYD88@INNATE_IMMUNE_CELL_Cytosol map
  16. gIRF1@INNATE_IMMUNE_CELL_Cytosol map → map rIRF1@INNATE_IMMUNE_CELL_Cytosol map
  17. gSOCS1@INNATE_IMMUNE_CELL_Cytosol map → map rSOCS1@INNATE_IMMUNE_CELL_Cytosol map
  18. gTNFR1*@INNATE_IMMUNE_CELL_Cytosol map → map rTNFR1*@INNATE_IMMUNE_CELL_Cytosol map
  19. gRIPK1@INNATE_IMMUNE_CELL_Cytosol map → map rRIPK1@INNATE_IMMUNE_CELL_Cytosol map
  20. gIFNG@INNATE_IMMUNE_CELL_Cytosol map → map rIFNG@INNATE_IMMUNE_CELL_Cytosol map
  21. gPRF1@INNATE_IMMUNE_CELL_Cytosol map → map rPRF1@INNATE_IMMUNE_CELL_Cytosol map
  22. gFASL*@INNATE_IMMUNE_CELL_Cytosol map → map rFASL*@INNATE_IMMUNE_CELL_Cytosol map
  23. gTRAIL*@INNATE_IMMUNE_CELL_Cytosol map → map rTRAIL*@INNATE_IMMUNE_CELL_Cytosol map