Identifiers
HUGO:DUSP1
Maps_Modules
MACROPHAGE
MODULE:CORE_SIGNALING_PATHWAYS
MODULE:IMMUNOSUPPPRESSIVE_CORE_PATHWAYS
CASCADE:IL13
CASCADE:IL10
References
PMID:23124025, PMID:16184516
IL13 induces DUSP1 expression via TYK2 and probably STAT6
In silico analysis identified a STAT6 binding site at position +99 (relative to the transcriptional start site) of the mouse DUSP1 promoter.
PMID:16184516
IL-10 induces the expression of DUSP1, which negatively regulates p38 phosphorylation and thus limits IL-10 production