Identifiers
HUGO:MAOA
Maps_Modules
MACROPHAGE
MODULE:TUMOR_KILLING
MODULE:EFFECTOR_ACTIVATION
MODULE:NO_ROS_PRODUCTION
CASCADE:IL4
CASCADE:IL13
References
PMID:23124025
IL13 induces expression of MAOA and ALOX15 via JAK1, TYK2, STAT1 STAT3 and STAT6
IL4 induces expression of MAOA and ALOX15 via JAK1, STAT3 and STAT6.
PMID:22067385
c-MYC expression is assosiated with M2 type of macrophages.
IL4 induces MYC expression in macrophages. MYC directly regulates some genes associated with alternative activation, including ARole of c-MYC in alternative activation of human macrophages and tumor-associated macrophage biology MAOA, PPARG, SCARB1, ALOX15, and MRC1, whereas others, including CD209, are indirectly regulated by c-MYC. c-MYC up-regulates the IL-4 signaling mediators signal transducer and activator of transcription-6 and peroxisome proliferator-activated receptorγ, is also expressed in tumor-associated macrophages, and its inhibition blocks the expression of protumoral genes including VEGF, MMP9, HIF-1A, and TGFB.